Iola sits at the crossroads of U.S. Route 54 and U.S. Route 169, nestled between Kansas’s Flint Hills and Missouri’s Ozarks. Enjoy Kansas’s quaint small-town and rural environment while staying within a 3-hour radius of five major cities. Hosting the largest downtown square in the United States, colorful historic buildings line the square’s eight blocks of unique shops, restaurants and historical attractions.